A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains
نویسندگان
چکیده
منابع مشابه
Protein multiple sequence alignment.
Protein sequence alignment is the task of identifying evolutionarily or structurally related positions in a collection of amino acid sequences. Although the protein alignment problem has been studied for several decades, many recent studies have demonstrated considerable progress in improving the accuracy or scalability of multiple and pairwise alignment tools, or in expanding the scope of task...
متن کاملMultiple protein sequence alignment.
Multiple sequence alignments are essential in computational analysis of protein sequences and structures, with applications in structure modeling, functional site prediction, phylogenetic analysis and sequence database searching. Constructing accurate multiple alignments for divergent protein sequences remains a difficult computational task, and alignment speed becomes an issue for large sequen...
متن کاملMultiple Sequence Alignment Multiple Sequence Alignment
An algorithm for progressive multiple alignment of sequences with insertions " , 1. Introduction The problem of sequence alignment is to find the patterns of sequence conservation and similarity between pairs or sets of given sequences. In biological contexts, similarity between biological sequences usually amounts to either functional or structural similarities or divergence from a common ance...
متن کاملA multiple sequence alignment program
A program is described for simultaneously aligning two or more molecular sequences which is based on first finding common segments above a specified length and then piecing these together to maximize an alignment scoring function. Optimal as well as near-optimal alignments are found, and there is also provided a means for randomizing the given sequences for testing the statistical significance ...
متن کاملA Parallel Hybrid Genetic Algorithm for Multiple Protein Sequence Alignment
This paper presents a parallel hybrid genetic algorithm (GA) for solving the sum-of-pairs multiple protein sequence alignment. The method is based on a multiple population GENITOR-type GA and involves local search heuristics. It is then extended to parallel to exploit the benefit of multiprocessor system. Benchmarks from the BAliBASE library are used to validate the method.
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-56499-4